If opioid manufacturers and distributors were hopeful they would escape the responsibility for poisoning millions of people, this next scientific article makes that wishful thinking an impossibility. If the FDA and the CDC were likewise hoping that they would escape the reality of their epic failure, again, this is but wishful thinking. The 2020 article by Sandoval-Sierra et al makes this, and all such wishful thinking, an impossibility. This article states, and with clarity, that opioids cause damage to the DNA. This article states, and with clarity, that opioids are a defective product that cause a poisoning to the human body. There is no escaping the reality of the study. There is no denying the science set forth by Sandoval-Sierra et al (2020). Opioids are a defective product poisoning, the body of any and everyone who is exposed to them.
Scientific Evidence that Opioids Cause the Methylation seen in the Promoter Region of the OPRM1 Gene
The study itself is stunningly simple. Sandoval – Sierra et al (2020) simply recruited opioid naïve volunteers from the local dental clinic. These are people with no history of prolonged opioid usage. These are people who will be prescribed opioids for pain control following their dental procedure. All Sandoval-Sierra et al (2020) did was to measure the DNA methylation before, during, and after a short course of opioids. And again the conclusion of the study could not be stated any clearer:
The present study provides evidence that the Hypermethylation of the OPRM1 Promoter is in response to opioid use.
It simply cannot be any clearer than this. These individuals had no abnormal damage to their DNA before they took opioids. Yet, after just a short course of opioids, the damage to the DNA was easily measurable. This study is a coffin nail for those who would have hoped to escape the culpability of their actions. Opioid pharmaceutical manufacturers and distributors are responsible for the poisoning of millions of people. Accountability is required. This is the need for this DNA test and the class action lawsuit to follow.
It is noted that Sandoval-Sierra et al (2020) does not report any occurrence of withdrawal symptoms. This is what suggests to us that some threshold of methylation must be crossed before symptoms of neurotoxicity can be seen.