We have already seen that the first prediction as a result of the Smith Hypothesis was not only accurate but was so profoundly accurate that the emergency halt measures by HHS for a clinical trial were triggered. We now move onto the second prediction as a result of the Smith Hypothesis – a detectable increase in coronary artery disease deaths in any population simultaneously experiencing an increase in opioid overdose deaths. In other words, individuals who find themselves without an accurate diagnosis and without proper treatment, when experiencing so-called “opioid withdrawal” are left with a dilemma- risk of death by a fentanyl overdose or risk of death by a heart attack. And the Smith Hypothesis is saying that these Catecholamine Surge induced heart attacks are so common and prevalent that these death by heart attacks can be easily measured in any population experiencing a surge in opioid overdose deaths. It is noted that the medical examiner would not note that the specific and individual coronary artery disease death would be opioid related. The simple explanation for this confusion is that no opioids would be found in the body. It was a lack of opioids and the ensuing autonomic dysfunction that led to the heart damage in the first place.
The logic here is simple and straightforward. Now that we know that a Catecholamine Surge is a component of the loss of control of the internal organs during what was previously known as so-called “opioid withdrawal”, we only need to recognize that a Catecholamine Surge is associated with cardiomyocyte necroptosis. Cardiomyocyte necroptosis is what the layperson would know as a heart attack. This is an admittedly oversimplification of the science, but we will allow the oversimplification for now. And let’s be crystal clear here, we are using as our yardstick for the accuracy of the Smith Hypothesis the endpoint of death by cardiomyocyte necroptosis. This is the most stringent endpoint possible- death by what the layperson would know as a heart attack. The cited article by Wu et al is titled “CATECHOLAMINE SURGE CAUSES CARDIOMYOCYTE NECROPTOSIS” (Figure 5). There is more to the title. But that’s all the knowledge that is required for now. Note the title includes the most powerful language of “CAUSES CARDIOMYOCYTE NECROPTOSIS.” The title doesn’t use the words “is associated with”. No, the title is very explicit- CAUSES. Cause is a powerful word in the scientific community.
Next, let’s just take a quick look at the nature of Coronary Artery Disease deaths (Figure 6). While the overall trend is noted to be a downward trend, what we would like for the reader to note is that surges in Coronary Artery Disease deaths (CAD deaths) simply is not a part of the landscape. Not a single surge in the death rate can be discerned from this multi year graph. Therefore, practically any surge in CAD deaths would beg for an explanation.